All HEI'sATU DonegalATU Galway-MayoATU SligoDublin City UniversityDun Laoghaire IADTDundalk ITMaynooth UniversityMTU CorkMTU KerryNational College of Ireland (NCI)NCADRoyal College of SurgeonsSETU CarlowSETU WaterfordTeagascTrinity College DublinTUD BlanchardstownTUD GrangegormonTUD TallaghtTUS AthloneTUS LimerickUniversity College CorkUniversity College DublinUniversity of GalwayUniversity of Limerick All SectorsFuture Networks and Communications, IoT Data Analytics, Management, Security, Privacy, Robotics and Artificial Intelligence (incl. Machine Learning)Digital Platforms, Content and Applications, Augmented & Virtual RealityConnected Health Medical DevicesDiagnosticsTherapeutics Food for HealthSmart & Sustainable Food Production and Processing Decarbonising the Energy SystemSustainable LivingAdvanced & Smart ManufacturingManufacturing & Novel MaterialsInnovation in Services and Business ProcessingSectorsResearch Theme Sub SectorsFKBPL: A NOVEL TARGET FOR OBESITY AND METABOLIC SYNDROMERCSI researchers have discovered a novel target, FKBPL, which regulates energy expenditure, and have shown that obesity and Type 2 diabetes (T2D) develop when levels of this protein are low in mice and humans. Proof of... pdf 272.8KBSTARMAT – A Versatile Star Polypeptide Platform for Oligonucleotide Drug DeliveryStar-polymers are a new class of polymer architecture which consist of linear arms radiating from a central core. Novel Star polypeptide-based vectors discovered at RCSI have superior transfection and delivery efficacy... pdf 436.5KBModulating macrophage plasticity for the treatment of diseaseResearchers in RCSI have discovered that enhancing the expression of a particular enzyme maintains macrophages in an anti-inflammatory and tissue regenerative state. They have developed a target site blocker which up-reg... pdf 305.4KBHighly Selective Inhibitors of HDAC6 for the Treatment of Cancers and Neurodegenerative DiseaseA novel structural class of highly-selective HDAC6 inhibitors. These patented small molecules have a unique non-hydroxamic acid chemical structure. The lead compound BAS-2 has been shown to inhibit glycolysis in triple ... pdf 463.4KBModifying Macrophages for the Treatment of Inflammatory DiseasesMacrophages are a sub-type of immune cells that are critical for fighting infection in the body through the release of inflammatory and toxic mediators. However if inflammation persists these Macrophages become destructi... pdf 306.3KB 12 Last Print Bookmark Top