Molecular Therapeutics for Cancer, Ireland (MTCI) is a Science Foundation Ireland (SFI) funded Strategic Research Cluster which aims to discover and develop new anti-cancer drugs.
The developmental process for new anticancer drugs has undergone radical change in the molecular era. Unlike the empirical approach used to discover chemotherapy drugs, the new approach is mechanistic and molecular.
Another critical difference is that the new approach is “translational”, i.e. it involves intense interaction between laboratory and clinical investigators. Thus, modern cancer drug development begins with recognition of clinical need, and progresses through molecular target identification, drug synthesis, pre-clinical testing, clinical trials and molecular analysis of tissue samples from treated patients
Many critical components of the development process for molecular cancer therapeutics exist in Ireland, but are dispersed across multiple institutions. Molecular Therapeutics for Cancer Ireland represents an attempt to capitalise on potential synergies between these resources, in order to develop Ireland as a site for cancer drug development.